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N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells

There is evidence suggesting that N-cadherin expression on osteoblast lineage cells regulates hematopoietic stem cell (HSC) function and quiescence. To test this hypothesis, we conditionally deleted N-cadherin (Cdh2) in osteoblasts using Cdh2(flox/flox) Osx-Cre mice. N-cadherin expression was effici...

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Autori principali: Greenbaum, Adam M., Revollo, Leila D., Woloszynek, Jill R., Civitelli, Roberto, Link, Daniel C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398761/
https://ncbi.nlm.nih.gov/pubmed/22323481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-377457
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