The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

Nuclear exclusion of the PTEN tumour suppressor has been associated with cancer progression(1-6). However, the mechanisms leading to this aberrant PTEN localization in human cancers are currently unknown. We have previously reported that ubiquitinylation of PTEN at specific lysine residues regulates...

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Bibliografiske detaljer
Main Authors: Song, Min Sup, Salmena, Leonardo, Carracedo, Arkaitz, Egia, Ainara, Lo-Coco, Francesco, Teruya-Feldstein, Julie, Pandolfi, Pier Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398484/
https://ncbi.nlm.nih.gov/pubmed/18716620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07290
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