Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines

Nucleotide excision repair (NER) has long been known to remove DNA lesions induced by chemical carcinogens, and the molecular mechanism has been partially elucidated. Here we demonstrate that in S.pombe a DNA recognition protein, alkyltransferase-like 1 (Atl1), can play a pivotal role in selecting a...

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Main Authors: Latypov, Vitaly F., Tubbs, Julie L., Watson, Amanda J., Marriott, Andrew S., McGown, Gail, Thorncroft, Mary, Wilkinson, Oliver J., Senthong, Pattama, Butt, Amna, Arvai, Andrew S., Millington, Christopher L., Povey, Andrew C., Williams, David M., Santibanez-Koref, Mauro F., Tainer, John A., Margison, Geoffrey P.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3398191/
https://ncbi.nlm.nih.gov/pubmed/22658721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.04.028
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