Myosin Regulatory Light Chain Diphosphorylation Slows Relaxation of Arterial Smooth Muscle

The principal signal to activate smooth muscle contraction is phosphorylation of the regulatory light chains of myosin (LC(20)) at Ser(19) by Ca(2+)/calmodulin-dependent myosin light chain kinase. Inhibition of myosin light chain phosphatase leads to Ca(2+)-independent phosphorylation at both Ser(19...

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Bibliographic Details
Main Authors: Sutherland, Cindy, Walsh, Michael P.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397833/
https://ncbi.nlm.nih.gov/pubmed/22661704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.371609
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