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Pro- and anti-inflammatory functions of the p38 pathway in rheumatoid arthritis: Advantages of targeting upstream kinases MKK3 or MKK6
OBJECTIVE: p38 inhibitors demonstrate limited benefit in rheumatoid arthritis (RA), perhaps due to anti-inflammatory functions of p38α. We determined if selective deletion of p38α in macrophages affects severity of arthritis. We also determined whether blocking upstream kinases in the p38 pathway, s...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3397277/ https://ncbi.nlm.nih.gov/pubmed/22488549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34489 |
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