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Pro- and anti-inflammatory functions of the p38 pathway in rheumatoid arthritis: Advantages of targeting upstream kinases MKK3 or MKK6

OBJECTIVE: p38 inhibitors demonstrate limited benefit in rheumatoid arthritis (RA), perhaps due to anti-inflammatory functions of p38α. We determined if selective deletion of p38α in macrophages affects severity of arthritis. We also determined whether blocking upstream kinases in the p38 pathway, s...

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Autori principali: Guma, Monica, Hammaker, Deepa, Topolewski, Katharyn, Corr, Maripat, Boyle, David L., Karin, Michael, Firestein, Gary S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397277/
https://ncbi.nlm.nih.gov/pubmed/22488549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34489
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