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Pro- and anti-inflammatory functions of the p38 pathway in rheumatoid arthritis: Advantages of targeting upstream kinases MKK3 or MKK6

OBJECTIVE: p38 inhibitors demonstrate limited benefit in rheumatoid arthritis (RA), perhaps due to anti-inflammatory functions of p38α. We determined if selective deletion of p38α in macrophages affects severity of arthritis. We also determined whether blocking upstream kinases in the p38 pathway, s...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Guma, Monica, Hammaker, Deepa, Topolewski, Katharyn, Corr, Maripat, Boyle, David L., Karin, Michael, Firestein, Gary S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397277/
https://ncbi.nlm.nih.gov/pubmed/22488549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34489
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