Autoimmune Epididymo-orchitis is Essential to the Pathogenesis of Male-Specific Spondyloarthritis in HLA-B27 Transgenic Rats

OBJECTIVE: Male rats transgenic for HLA-B27 and human-β2-microglobulin (Hu-β2m) spontaneously develop epididymo-orchitis preceding spondyloarthritis. In the specific B27/Hu-β2m transgenic cross (21-3x382-2)F1, only the males develop spondyloarthritis, and neither sex develops gut inflammation. We as...

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Main Authors: Taurog, Joel D., Rival, Claudia, van Duivenvoorde, Leonie M., Satumtira, Nimman, Dorris, Martha L., Sun, Margaret, Shelton, John M., Richardson, James A., Hamra, F. Kent, Hammer, Robert E., Tung, Kenneth S. K.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3396784/
https://ncbi.nlm.nih.gov/pubmed/22488218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34480
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