Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8(+) T cells are not required for disease induction in the HLA-B27/Huβ2m transgenic rats. We used Lewis HLA-B27/Huβ2m transgenic rats [21-3 × 283-2]F1, HLA-B7/Huβ2...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: van Tok, Melissa N., Satumtira, Nimman, Dorris, Martha, Pots, Desirée, Slobodin, Gleb, van de Sande, Marleen G., Taurog, Joel D., Baeten, Dominique L., van Duivenvoorde, Leonie M.
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5545590/
https://ncbi.nlm.nih.gov/pubmed/28824645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00920
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