The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion

HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown mechanism. ERAP1 is an aminopeptidase that trims peptides in the endoplasmic reticulum for binding to MHC-I molecules. ERAP1 shows genetic epist...

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Udgivet i:Mol Cell Proteomics
Main Authors: Barnea, Eilon, Melamed Kadosh, Dganit, Haimovich, Yael, Satumtira, Nimman, Dorris, Martha L., Nguyen, Mylinh T., Hammer, Robert E., Tran, Tri M., Colbert, Robert A., Taurog, Joel D., Admon, Arie
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Biochemistry and Molecular Biology 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383784/
https://ncbi.nlm.nih.gov/pubmed/28188227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.066241
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