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Synthesis of nucleic acid methylphosphonates via the 1-hydroxybenzotriazole phosphotriester approach.
Dinucleoside methylphosphonates can easily be prepared starting from properly protected d-nucleosides and the bifunctional phosphorylating reagent methyl-O,O-bis(1-benzotriazolyl)phosphate. Separation of the diastereoisomers of 5'-DMTR-d-Ap(Me)T-3'-lev affords optically pure dinucleoside m...
Kaydedildi:
| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
1986
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| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC339650/ https://ncbi.nlm.nih.gov/pubmed/3457366 |
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