Synthesis of nucleic acid methylphosphonates via the 1-hydroxybenzotriazole phosphotriester approach.

Dinucleoside methylphosphonates can easily be prepared starting from properly protected d-nucleosides and the bifunctional phosphorylating reagent methyl-O,O-bis(1-benzotriazolyl)phosphate. Separation of the diastereoisomers of 5'-DMTR-d-Ap(Me)T-3'-lev affords optically pure dinucleoside methylphosp...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Marugg, J E, de Vroom, E, Dreef, C E, Tromp, M, van der Marel, G A, van Boom, J H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1986
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339650/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3457366/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.5.2171
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