Synthesis of nucleic acid methylphosphonates via the 1-hydroxybenzotriazole phosphotriester approach.

Dinucleoside methylphosphonates can easily be prepared starting from properly protected d-nucleosides and the bifunctional phosphorylating reagent methyl-O,O-bis(1-benzotriazolyl)phosphate. Separation of the diastereoisomers of 5'-DMTR-d-Ap(Me)T-3'-lev affords optically pure dinucleoside methylphosp...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Marugg, J E, de Vroom, E, Dreef, C E, Tromp, M, van der Marel, G A, van Boom, J H
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 1986
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC339650/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3457366/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/14.5.2171
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