Discovery and Optimization of Benzotriazine Di-N-Oxides Targeting Replicating and Non-replicating Mycobacterium tuberculosis

Compounds bactericidal against both replicating and non-replicating Mtb may shorten the length of TB treatment regimens by eliminating infections more rapidly. Screening of a panel of antimicrobial and anticancer drug classes that are bioreduced into cytotoxic species revealed that 1,2,4-benzotriazi...

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Detalhes bibliográficos
Main Authors: Chopra, Sidharth, Koolpe, Gary A., Tambo-ong, Arlyn A., Matsuyama, Karen N., Ryan, Kenneth J., Tran, Tran B., Doppalapudi, Rupa S., Riccio, Edward S., Iyer, Lalitha V., Green, Carol E., Wan, Baojie, Franzblau, Scott G., Madrid, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3395780/
https://ncbi.nlm.nih.gov/pubmed/22691154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300123s
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