Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis

OBJECTIVES: New classes of drugs are needed to treat tuberculosis (TB) in order to combat the emergence of resistance to existing agents and shorten the duration of therapy. Targeting DNA gyrase is a clinically validated therapeutic approach using fluoroquinolone antibiotics to target the gyrase sub...

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Autors principals: Chopra, Sidharth, Matsuyama, Karen, Tran, Tran, Malerich, Jeremiah P., Wan, Baojie, Franzblau, Scott G., Lun, Shichun, Guo, Haidan, Maiga, Mariama C., Bishai, William R., Madrid, Peter B.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254195/
https://ncbi.nlm.nih.gov/pubmed/22052686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr449
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