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Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities
Synthetic derivatives of the natural product antibiotic novobiocin were synthesized in order to improve their physiochemical properties. A Mannich reaction was used to introduce new side chains at a solvent-exposed position of the molecule, and a diverse panel of functional groups was evaluated at t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3178263/ https://ncbi.nlm.nih.gov/pubmed/21871799 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2011.08.035 |
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