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Enhancing Hit Identification in Mycobacterium tuberculosis Drug Discovery Using Validated Dual-Event Bayesian Models

High-throughput screening (HTS) in whole cells is widely pursued to find compounds active against Mycobacterium tuberculosis (Mtb) for further development towards new tuberculosis (TB) drugs. Hit rates from these screens, usually conducted at 10 to 25 µM concentrations, typically range from less tha...

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Bibliografische gegevens
Hoofdauteurs: Ekins, Sean, Reynolds, Robert C., Franzblau, Scott G., Wan, Baojie, Freundlich, Joel S., Bunin, Barry A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647004/
https://ncbi.nlm.nih.gov/pubmed/23667592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063240
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