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Combining Computational Methods for Hit to Lead Optimization in Mycobacterium tuberculosis Drug Discovery

PURPOSE: Tuberculosis treatments need to be shorter and overcome drug resistance. Our previous large scale phenotypic high-throughput screening against Mycobacterium tuberculosis (Mtb) has identified 737 active compounds and thousands that are inactive. We have used this data for building computatio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ekins, Sean, Freundlich, Joel S., Hobrath, Judith V., White, E. Lucile, Reynolds, Robert C
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946937/
https://ncbi.nlm.nih.gov/pubmed/24132686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1172-7
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