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Combining Computational Methods for Hit to Lead Optimization in Mycobacterium tuberculosis Drug Discovery
PURPOSE: Tuberculosis treatments need to be shorter and overcome drug resistance. Our previous large scale phenotypic high-throughput screening against Mycobacterium tuberculosis (Mtb) has identified 737 active compounds and thousands that are inactive. We have used this data for building computatio...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3946937/ https://ncbi.nlm.nih.gov/pubmed/24132686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-013-1172-7 |
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