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Presenilins: A novel link between intracellular calcium signaling and lysosomal function?
Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer’s disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FAD-associated PS mutations, which have been previously attributed to...
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
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The Rockefeller University Press
2012
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392935/ https://ncbi.nlm.nih.gov/pubmed/22778275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206003 |
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