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Presenilins and calcium signaling – systems biology to the rescue
Mutations in presenilins result in familial Alzheimer’s disease (FAD). Presenilins encode a catalytic subunit of γ-secretase complex, and FAD mutations in presenilins alter γ-secretase activity. Many FAD mutations in presenilins also affect intracellular calcium signaling. To explain these results i...
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| Publicado no: | Sci Signal |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5018382/ https://ncbi.nlm.nih.gov/pubmed/23838181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004296 |
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