PRESENILIN-NULL CELLS HAVE ALTERED TWO-PORE CALCIUM CHANNEL EXPRESSION AND LYSOSOMAL CALCIUM; IMPLICATIONS FOR LYSOSOMAL FUNCTION

Presenilins are necessary for calcium homeostasis and also for efficient proteolysis through the autophagy/lysosome system. Presenilin regulates both endoplasmic reticulum calcium stores and autophagic proteolysis in a γ-secretase independent fashion. The endo-lysosome system can also act as a calci...

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Bibliografiske detaljer
Main Authors: Kayala, Kara M Neely, Dickinson, George D, Minassian, Anet, Walls, Ken C, Green, Kim N, LaFerla, Frank M
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516298/
https://ncbi.nlm.nih.gov/pubmed/23103503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2012.10.036
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