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Presenilins: A novel link between intracellular calcium signaling and lysosomal function?
Mutations in presenilins (PS), transmembrane proteins encoding the catalytic subunit of γ-secretase, result in familial Alzheimer’s disease (FAD). Several studies have identified lysosomal defects in cells lacking PS or expressing FAD-associated PS mutations, which have been previously attributed to...
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| Autor principal: | |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2012
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3392935/ https://ncbi.nlm.nih.gov/pubmed/22778275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201206003 |
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