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Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

Caspase-2 has been implicated in apoptosis and in non-apoptotic processes such as cell cycle regulation, tumor suppression and ageing. Using caspase-2 knockout (casp2(−/−)) mice, we show here that the putative anti-ageing role of this caspase is due in part to its involvement in the stress response...

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Autores principales: Shalini, S, Dorstyn, L, Wilson, C, Puccini, J, Ho, L, Kumar, S
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392626/
https://ncbi.nlm.nih.gov/pubmed/22343713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.13
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