AAV-Mediated Gene Targeting Is Significantly Enhanced by Transient Inhibition of Nonhomologous End Joining or the Proteasome In Vivo

Recombinant adeno-associated virus (rAAV) vectors have clear potential for use in gene targeting but low correction efficiencies remain the primary drawback. One approach to enhancing efficiency is a block of undesired repair pathways like nonhomologous end joining (NHEJ) to promote the use of homol...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Paulk, Nicole K., Loza, Laura Marquez, Finegold, Milton J., Grompe, Markus
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392621/
https://ncbi.nlm.nih.gov/pubmed/22486314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.038
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares