AAV-Mediated Gene Targeting Is Significantly Enhanced by Transient Inhibition of Nonhomologous End Joining or the Proteasome In Vivo

Recombinant adeno-associated virus (rAAV) vectors have clear potential for use in gene targeting but low correction efficiencies remain the primary drawback. One approach to enhancing efficiency is a block of undesired repair pathways like nonhomologous end joining (NHEJ) to promote the use of homol...

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Main Authors: Paulk, Nicole K., Loza, Laura Marquez, Finegold, Milton J., Grompe, Markus
Formato: Artigo
Idioma:Inglês
Publicado: Mary Ann Liebert, Inc. 2012
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392621/
https://ncbi.nlm.nih.gov/pubmed/22486314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.038
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