Liver fibrosis and hepatocyte apoptosis are attenuated by GKT137831 a novel NOX4/NOX1 inhibitor in vivo

Reactive oxygen species (ROS) play a key role in chronic liver injury and fibrosis. Homologues of NADPH oxidases (NOXs) are major sources of ROS, but the exact role of the individual homologues in liver disease is unknown. Our goal was to determine the role of NOX4 in liver fibrosis induced by bile...

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Autores principales: Jiang, Joy X., Chen, Xiangling, Serizawa, Nobuko, Szyndralewiez, Cedric, Page, Patrick, Schröder, Katrin, Brandes, Ralf P., Devaraj, Sridevi, Török, Natalie J
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392471/
https://ncbi.nlm.nih.gov/pubmed/22618020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.05.007
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