Selective and Specific Inhibition of the Plasmodium falciparum Lysyl-tRNA Synthetase by the Fungal Secondary Metabolite Cladosporin

With renewed calls for malaria eradication, next-generation antimalarials need be active against drug-resistant parasites and efficacious against both liver- and blood-stage infections. We screened a natural product library to identify inhibitors of Plasmodium falciparum blood- and liver-stage proli...

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Main Authors: Hoepfner, Dominic, McNamara, Case W., Lim, Chek Shik, Studer, Christian, Riedl, Ralph, Aust, Thomas, McCormack, Susan L., Plouffe, David M., Meister, Stephan, Schuierer, Sven, Plikat, Uwe, Hartmann, Nicole, Staedtler, Frank, Cotesta, Simona, Schmitt, Esther K., Petersen, Frank, Supek, Frantisek, Glynne, Richard J., Tallarico, John A., Porter, Jeffrey A., Fishman, Mark C., Bodenreider, Christophe, Diagana, Thierry T., Movva, N. Rao, Winzeler, Elizabeth A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391680/
https://ncbi.nlm.nih.gov/pubmed/22704625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2012.04.015
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