Evidence for a functionally relevant rocaglamide binding site on the eIF4A:RNA complex

Translation initiation is an emerging target in oncology and neurobiology indications. Naturally derived and synthetic rocaglamide scaffolds have been used to interrogate this pathway, however, there is uncertainty regarding their precise mechanism(s) of action. We exploited the genetic tractability...

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Detalhes bibliográficos
Main Authors: Sadlish, Heather, Galicia-Vazquez, Gabriela, Paris, C. Gregory, Aust, Thomas, Bhullar, Bhupinder, Chang, Lena, Helliwell, Stephen B., Hoepfner, Dominic, Knapp, Britta, Riedl, Ralph, Roggo, Silvio, Schuierer, Sven, Studer, Christian, Porco, John A., Pelletier, Jerry, Movva, N. Rao
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3796129/
https://ncbi.nlm.nih.gov/pubmed/23614532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400158t
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