Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A

The translation inhibitor rocaglamide A (RocA) has shown promising antitumor activity because it uniquely clamps eukaryotic initiation factor (eIF) 4A onto polypurine RNA for selective translational repression. As eIF4A has been speculated to be a unique target of RocA, alternative targets have not...

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Publié dans:Cell Chem Biol
Auteurs principaux: Chen, Mingming, Asanuma, Miwako, Takahashi, Mari, Shichino, Yuichi, Mito, Mari, Fujiwara, Koichi, Saito, Hironori, Floor, Stephen N., Ingolia, Nicholas T., Sodeoka, Mikiko, Dodo, Kosuke, Ito, Takuhiro, Iwasaki, Shintaro
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052261/
https://ncbi.nlm.nih.gov/pubmed/33296667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.11.008
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