The Translation Inhibitor Rocaglamide Targets a Biomolecular Cavity between eIF4A and Polypurine RNA

A class of translation inhibitors, exemplified by the natural product Rocaglamide A (RocA), isolated from Aglaia genus plants, exhibits antitumor activity by clamping eukaryotic translation initiation factor 4A (eIF4A) onto polypurine sequences in mRNAs. This unusual inhibitory mechanism raises the...

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Publié dans:Mol Cell
Auteurs principaux: Iwasaki, Shintaro, Iwasaki, Wakana, Takahashi, Mari, Sakamoto, Ayako, Watanabe, Chiduru, Shichino, Yuichi, Floor, Stephen N., Fujiwara, Koichi, Mito, Mari, Dodo, Kosuke, Sodeoka, Mikiko, Imataka, Hiroaki, Honma, Teruki, Fukuzawa, Kaori, Ito, Takuhiro, Ingolia, Nicholas T.
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6386617/
https://ncbi.nlm.nih.gov/pubmed/30595437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.026
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