Auxin-Inducible Depletion of the Essentialome Suggests Inhibition of TORC1 by Auxins and Inhibition of Vrg4 by SDZ 90-215, a Natural Antifungal Cyclopeptide

Gene knockout and knockdown strategies have been immensely successful probes of gene function, but small molecule inhibitors (SMIs) of gene products allow much greater time resolution and are particularly useful when the targets are essential for cell replication or survival. SMIs also serve as lead...

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Detalhes bibliográficos
Publicado no:G3 (Bethesda)
Main Authors: Snyder, Nathan A., Kim, Adam, Kester, Louis, Gale, Andrew N., Studer, Christian, Hoepfner, Dominic, Roggo, Silvio, Helliwell, Stephen B., Cunningham, Kyle W.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2019
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404609/
https://ncbi.nlm.nih.gov/pubmed/30670608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.118.200748
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