Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia

Effective targeted cancer therapeutic development depends upon distinguishing disease-associated ‘driver’ mutations, which have causative roles in malignancy pathogenesis, from ‘passenger’ mutations, which are dispensable for cancer initiation and maintenance. Translational studies of clinically act...

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Detalhes bibliográficos
Main Authors: Smith, Catherine C., Wang, Qi, Chin, Chen-Shan, Salerno, Sara, Damon, Lauren E., Levis, Mark J., Perl, Alexander E., Travers, Kevin J., Wang, Susana, Hunt, Jeremy P., Zarrinkar, Patrick P., Schadt, Eric E., Kasarskis, Andrew, Kuriyan, John, Shah, Neil P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390926/
https://ncbi.nlm.nih.gov/pubmed/22504184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature11016
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