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A Network of Ubiquitin Ligases Is Important for the Dynamics of Misfolded Protein Aggregates in Yeast

Quality control ubiquitin ligases promote degradation of misfolded proteins by the proteasome. If the capacity of the ubiquitin/proteasome system is exceeded, then misfolded proteins accumulate in aggregates that are cleared by the autophagic system. To identify components of the ubiquitin/proteasom...

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Autores principales: Theodoraki, Maria A., Nillegoda, Nadinath B., Saini, Jagdeep, Caplan, Avrom J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390667/
https://ncbi.nlm.nih.gov/pubmed/22593585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.341164
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