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High-Affinity Target Binding Engineered via Fusion of a Single-Domain Antibody Fragment with a Ligand-Tailored SH3 Domain

Monoclonal and recombinant antibodies are ubiquitous tools in diagnostics, therapeutics, and biotechnology. However, their biochemical properties lack optimal robustness, their bacterial production is not easy, and possibilities to create multifunctional fusion proteins based on them are limited. Mo...

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Главные авторы: Järviluoma, Annika, Strandin, Tomas, Lülf, Sebastian, Bouchet, Jérôme, Mäkelä, Anna R., Geyer, Matthias, Benichou, Serge, Saksela, Kalle
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390362/
https://ncbi.nlm.nih.gov/pubmed/22792285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040331
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