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Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody
BACKGROUND: The HIV-1 Nef protein is essential for AIDS pathogenesis by its interaction with host cell surface receptors and signaling factors. Despite its critical role as a virulence factor Nef is not targeted by current antiviral strategies. RESULTS: We have determined the crystal structure of th...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007562/ https://ncbi.nlm.nih.gov/pubmed/24620746 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-11-24 |
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