Engineered SH2 domains with tailored specificities and enhanced affinities for phosphoproteome analysis

Protein phosphorylation is the most abundant post‐translational modification in cells. Src homology 2 (SH2) domains specifically recognize phosphorylated tyrosine (pTyr) residues to mediate signaling cascades. A conserved pocket in the SH2 domain binds the pTyr side chain and the EF and BG loops det...

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Veröffentlicht in:Protein Sci
Hauptverfasser: Veggiani, Gianluca, Huang, Haiming, Yates, Bradley P., Tong, Jiefei, Kaneko, Tomonori, Joshi, Rakesh, Li, Shawn S.C., Moran, Michael F., Gish, Gerald, Sidhu, Sachdev S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Inc. 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319756/
https://ncbi.nlm.nih.gov/pubmed/30431205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3551
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