Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands

The Src Homology-3 (SH3) domains are ubiquitous protein modules that mediate important intracellular protein interactions via binding to short proline-rich consensus motifs in their target proteins. The affinity and specificity of such core SH3 - ligand contacts are typically modest, but additional...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Kazlauskas, Arunas, Schmotz, Constanze, Kesti, Tapio, Hepojoki, Jussi, Kleino, Iivari, Kaneko, Tomonori, Li, Shawn S.C., Saksela, Kalle
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5054349/
https://ncbi.nlm.nih.gov/pubmed/27440912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M116.060483
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