ER Stress Is Involved in T17M Rhodopsin-Induced Retinal Degeneration

PURPOSE. The human rhodopsin (Rho) mutation T17M leads to autosomal dominant retinitis pigmentosa (adRP). The goal of our study was to elucidate the role of endoplasmic reticulum (ER) stress in retinal degeneration in hT17M Rho mice and identify potential candidates for adRP gene therapy. METHODS. W...

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Hauptverfasser: Kunte, Mansi M., Choudhury, Shreyasi, Manheim, Jessica F., Shinde, Vishal M., Miura, Masayuki, Chiodo, Vince A., Hauswirth, William W., Gorbatyuk, Oleg S., Gorbatyuk, Marina S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Association for Research in Vision and Ophthalmology 2012
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390184/
https://ncbi.nlm.nih.gov/pubmed/22589437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-9235
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