Dual-Fluorophore Quantitative High-throughput Screen for Inhibitors of BRCT-Phosphoprotein Interaction

Finding specific small-molecule inhibitors of protein-protein interactions remains a significant challenge. Recently, attention has grown toward “hot-spot” interactions where binding is dominated by a limited number of amino acid contacts, theoretically offering an increased opportunity for disrupti...

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Bibliographic Details
Main Authors: Simeonov, Anton, Yasgar, Adam, Jadhav, Ajit, Lokesh, G. L., Klumpp, Carleen, Michael, Sam, Austin, Christopher P., Natarajan, Amarnath, Inglese, James
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389998/
https://ncbi.nlm.nih.gov/pubmed/18158907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2007.11.039
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