Synthesis and Evaluation of in Vitro Bioactivity for Vesicular Acetylcholine Transporter Inhibitors Containing Two Carbonyl Groups

To identify selective high-affinity ligands for the vesicular acetylcholine transporter (VAChT), we have incorporated a carbonyl group into the structures of trozamicol and prezamicol scaffolds, and also converted the secondary amines of the piperidines of trozamicols and prezamicols into amides. Of...

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Main Authors: Tu, Zhude, Wang, Wei, Cui, Jinquan, Zhang, Xiang, Lu, Xiaoxia, Xu, Jinbin, Parsons, Stanley M.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389281/
https://ncbi.nlm.nih.gov/pubmed/22739089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.045
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