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Synthesis, In Vitro and In Vivo Evaluation of (18)F-labeled PET Ligands for Imaging the Vesicular Acetylcholine Transporter
A new class of vesicular acetylcholine transporter inhibitor that incorporates a carbonyl group into the benzovesamicol structure was synthesized and analogs were evaluated in vitro. (±)-trans-2-Hydroxy-3-(4-(4-[(18)F]fluorobenzoyl)piperidino)tetralin (9e) has K(i) values of 2.70 nM for VAChT, 191 n...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765529/ https://ncbi.nlm.nih.gov/pubmed/19203271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8012344 |
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