Synthesis, In Vitro and In Vivo Evaluation of (18)F-labeled PET Ligands for Imaging the Vesicular Acetylcholine Transporter

A new class of vesicular acetylcholine transporter inhibitor that incorporates a carbonyl group into the benzovesamicol structure was synthesized and analogs were evaluated in vitro. (±)-trans-2-Hydroxy-3-(4-(4-[(18)F]fluorobenzoyl)piperidino)tetralin (9e) has K(i) values of 2.70 nM for VAChT, 191 n...

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Autori principali: Tu, Zhude, Efange, Simon M. N., Xu, Jinbin, Li, Shihong, Jones, Lynne A., Parsons, Stanley M., Mach, Robert H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765529/
https://ncbi.nlm.nih.gov/pubmed/19203271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8012344
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