Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae vs human acetylcholinesterase

To identify potential human-safe insecticides against the malaria mosquito we undertook an investigation of the structure activity relationship of aryl methylcarbamates inhibitors of acetylcholinesterase (AChE). Compounds bearing a β-branched 2-alkoxy or 2-thioalkyl group were found to possess good...

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Detalhes bibliográficos
Main Authors: Hartsel, Joshua A., Wong, Dawn M., Mutunga, James M., Ma, Ming, Anderson, Troy D., Wysinski, Ania, Islam, Rafique, Wong, Eric A., Paulson, Sally L., Li, Jianyong, Lam, Polo C. H., Totrov, Maxim, Bloomquist, Jeffrey R., Carlier, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389130/
https://ncbi.nlm.nih.gov/pubmed/22738634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.103
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