3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae

To identify potential selective and resistance-breaking mosquitocides against the African malaria vector Anopheles gambiae, we investigated the acetylcholinesterase (AChE) inhibitory and mosquitocidal properties of isoxazol-3-yl dimethylcarbamates (15), and the corresponding 3-oxoisoxazole-2(3H)-dim...

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Publicat a:Bioorg Med Chem
Autors principals: Verma, Astha, Wong, Dawn M., Islam, Rafique, Tong, Fan, Ghavami, Maryam, Mutunga, James M., Slebodnick, Carla, Li, Jianyong, Viayna, Elisabet, Lam, Polo C.-H., Totrov, Maxim M., Bloomquist, Jeffrey R., Carlier, Paul R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346421/
https://ncbi.nlm.nih.gov/pubmed/25684426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.01.026
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