Aryl methylcarbamates: potency and selectivity towards wild-type and carbamate-insensitive (G119S) Anopheles gambiae acetylcholinesterase, and toxicity to G3 Strain An. gambiae

New carbamates that are highly selective for inhibition of Anopheles gambiae acetylcholinesterase (AChE) over the human enzyme might be useful in continuing efforts to limit malaria transmission. In this report we assessed 34 synthesized and commercial carbamates for their selectivity to inhibit the...

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Detalhes bibliográficos
Main Authors: Wong, Dawn M., Li, Jianyong, Lam, Polo C.H., Hartsel, Joshua A., Mutunga, James M., Totrov, Maxim, Bloomquist, Jeffrey R., Carlier, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578073/
https://ncbi.nlm.nih.gov/pubmed/22989775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2012.09.001
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