Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae vs human acetylcholinesterase

To identify potential human-safe insecticides against the malaria mosquito we undertook an investigation of the structure activity relationship of aryl methylcarbamates inhibitors of acetylcholinesterase (AChE). Compounds bearing a β-branched 2-alkoxy or 2-thioalkyl group were found to possess good...

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Main Authors: Hartsel, Joshua A., Wong, Dawn M., Mutunga, James M., Ma, Ming, Anderson, Troy D., Wysinski, Ania, Islam, Rafique, Wong, Eric A., Paulson, Sally L., Li, Jianyong, Lam, Polo C. H., Totrov, Maxim, Bloomquist, Jeffrey R., Carlier, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389130/
https://ncbi.nlm.nih.gov/pubmed/22738634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.103
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