HtrA2 deficiency causes mitochondrial uncoupling through the F(1)F(0)-ATP synthase and consequent ATP depletion

Loss of the mitochondrial protease HtrA2 (Omi) in mice leads to mitochondrial dysfunction, neurodegeneration and premature death, but the mechanism underlying this pathology remains unclear. Using primary cultures from wild-type and HtrA2-knockout mice, we find that HtrA2 deficiency significantly re...

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Detaylı Bibliyografya
Asıl Yazarlar: Plun-Favreau, H, Burchell, V S, Holmström, K M, Yao, Z, Deas, E, Cain, K, Fedele, V, Moisoi, N, Campanella, M, Miguel Martins, L, Wood, N W, Gourine, A V, Abramov, A Y
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388244/
https://ncbi.nlm.nih.gov/pubmed/22739987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.77
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