Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness

The synthetic double-stranded RNA poly(I:C) is commonly used as an adjuvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also suppress autoimmune disease. The mechanism by which a single adjuvant achieves two distinct immunoregulatory roles is unknown. Altho...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Ngoi, Soo Mun, St. Rose, Marie-Clare, Menoret, Antoine M., Smith, Dirk E., Tovey, Michael G., Adler, Adam J., Vella, Anthony T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2012
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387033/
https://ncbi.nlm.nih.gov/pubmed/22689946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202607109
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi