Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness

The synthetic double-stranded RNA poly(I:C) is commonly used as an adjuvant to boost CD8 T-cell function; however, polyinosinic:polycytidylic acid [poly(I:C)] can also suppress autoimmune disease. The mechanism by which a single adjuvant achieves two distinct immunoregulatory roles is unknown. Altho...

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Detalhes bibliográficos
Main Authors: Ngoi, Soo Mun, St. Rose, Marie-Clare, Menoret, Antoine M., Smith, Dirk E., Tovey, Michael G., Adler, Adam J., Vella, Anthony T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387033/
https://ncbi.nlm.nih.gov/pubmed/22689946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202607109
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