Costimulation endows immunotherapeutic CD8 T cells with IL-36-responsiveness during aerobic glycolysis

CD134 and CD137 primed CD8 T cells mount powerful effector responses upon recall, but even without recall these dual costimulated T cells respond to signal 3 cytokines like IL-12. We searched for alternative signal 3 receptor pathways and found the IL-1 family member IL-36R. While IL-36 alone did no...

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Udgivet i:J Immunol
Main Authors: Tsurutani, Naomi, Mittal, Payal, St Rose, Marie-Clare, Ngoi, Soo Mun, Svedova, Julia, Treadway, Forrest B., Laubenbacher, Reinhard, Suárez-Ramírez, Jenny E., Cauley, Linda S., Adler, Adam J., Vella, Anthony T.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4685023/
https://ncbi.nlm.nih.gov/pubmed/26573834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501217
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