Immediate antiviral therapy appears to restrict resting CD4(+) cell HIV-1 infection without accelerating the decay of latent infection

HIV type 1 (HIV-1) persists within resting CD4(+) T cells despite antiretroviral therapy (ART). To better understand the kinetics by which resting cell infection (RCI) is established, we developed a mathematical model that accurately predicts (r = 0.65, P = 2.5 × 10(−4)) the initial frequency of RCI...

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Main Authors: Archin, Nancie M., Vaidya, Naveen K., Kuruc, JoAnn D., Liberty, Abigail L., Wiegand, Ann, Kearney, Mary F., Cohen, Myron S., Coffin, John M., Bosch, Ronald J., Gay, Cynthia L., Eron, Joseph J., Margolis, David M., Perelson, Alan S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2012
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3386138/
https://ncbi.nlm.nih.gov/pubmed/22645358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120248109
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